RESUMEN
Objective: To evaluate the comorbidities in hospitalized patients with COVID-19 and identify which ones are associated with severe COVID-19 disease and/or in-hospital mortality. Methods: Unicenter retrospective cohort study was performed. All patients admitted with confirmed COVID-19 from March 1 to May 31, 2020 were included consecutively. A descriptive analysis of comorbidities at admission was made. We evaluated what comorbidities are associated with in-hospital mortality and/or severe COVID-19 disease using a binary logistic regression model. Results: A total of 336 patients were included in the study: 284 (84,5%) were discharged and 52 (15,5%) died during hospitalization. The diagnosis of COVID-19 was made by SARS-CoV-2 polymerase chain reaction in 317 patients (94%). Mean age was 66 + 14 years, 58% were men and Charlson Comorbidity Index was 1. In multivariate analysis, age >65 years (OR 2,65;95%CI 1,15 to 6,10;p 0,021), male sex (OR 3,26;95%CI 1,47 to 7,24;p 0,004), atherosclerotic cardiovascular disease (OR 2,11;95%CI 1,03 to 4,29;p 0,040), non-atherosclerotic cardiovascular disease (OR 6,40;95%CI 2,25 to 18,21, p<0,001) and malignancy (OR 5,09;95%CI 2,28 to 11,34;p< 0,001), were identified as comorbidities associated with in hospital-mortality. Age >65 years (OR 1,87;95%CI 1,05 to 3,34;p 0,033), male sex (OR 2,86;95%CI 1,58 to 5,17;p<0,001), obesity (OR 1,82;95%CI 1,04 to 3,18;p 0,034) and obstructive sleep apnea (OR 5,26;95%CI 1,60 to 17,25;p 0,006) were associated with severe COVID-19 disease. Conclusions: Previous cardiovascular disease and malignancy are risk factors of in-hospital mortality while obesity and obstructive sleep apnea are associated with severe COVID-19 disease in hospitalized patients. Age >65 years and male sex are associated with both.